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What is a Neuromuscular Junction?

Mary McMahon
Mary McMahon
Mary McMahon
Mary McMahon

A neuromuscular junction is a place in the body where the axons of motor nerves meet the muscle, allowing them to transmit messages from the brain that cause the muscle to contract and relax. Every organism has thousands of these junctions that control the movements of the body and cause the heart to beat. It is only one example of many connections made between nerves and other parts of the body that result in a successfully functioning organism.

Neurons, or nerve cells, are specially designed cells that communicate using chemicals called neurotransmitters. Depending on the type of cell, specific neurotransmitters are designed to stimulate a response, assuming that a receptor is present. In addition to a body, neurons also have a long tail called an axon that terminates in dendrites, a bundle of fibers that can transmit chemicals to the next neuron. In the instance of a neuromuscular junction, one neuron can control many muscle cells, but each muscle cell only responds to one neuron.

A neuromuscular junction plays an important part in muscle movement.
A neuromuscular junction plays an important part in muscle movement.

At this junction, the motor neuron meets muscle tissue at an axion terminal. The surface of the muscle fiber forms small ridged folds for the end of axon to rest in. Inside these folds are depressions with acetylcholine receptors. The neuron forms synaptic vesicles that are filled with acetylcholine. They resemble small bulbs that will release the neurotransmitter when the muscle needs to contract.

Neuromuscular junctions begin to grow during fetal development.
Neuromuscular junctions begin to grow during fetal development.

The neuromuscular junction is crucial for life, and they begin forming early in fetal development. As motor neurons develop, a protein called agrin is made. This stimulates the formation of a muscle specific kinase, which will build receptors for acetylcholine on the surface of the muscle fiber. This is how the junction is formed, with the neuron itself emitting the needed chemical for development.

Neurons are specially designed cells that communicate using chemicals called neurotransmitters.
Neurons are specially designed cells that communicate using chemicals called neurotransmitters.

Several conditions can cause malfunctions at these sites, leading to loss of muscle control. Ultimately, lack of muscle control can cause death if it is severe, because the body's largest muscle, the heart, could stop beating. The most common such illness is myasthenia gravis, which is caused by an autoimmune reaction against acetylcholine receptors. As a result, motor neurons cannot transmit the chemical to the muscles, which will cause muscle weakness and an ultimate loss of control.

Myasthenia gravis tends to be more concentrated along skeletal muscles and is especially noticeable in the face. Additionally, some toxins, such as botulinum, will inhibit the release of acetylcholine, which will lead to muscle paralysis.

Mary McMahon
Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a TheHealthBoard researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Learn more...
Mary McMahon
Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a TheHealthBoard researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Learn more...

Discussion Comments

anon34433

Overall this is an acceptable answer. However, neurons do not cause the hearts of all species to beat (ie from frogs to humans). Each heart beat is generated by specialized heart cells (sinoatrial nodal cells) that generate there own spontaneous active. Rather, the nerves regulate the frequency of beating.

anon30539

Describe the factors that lead to a muscle contraction, from the neuron to the neuro-muscular junction, what is happening at each part within the muscle cell and its organelles, leading to contraction in the muscle cell fibers.

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    • A neuromuscular junction plays an important part in muscle movement.
      By: Syda Productions
      A neuromuscular junction plays an important part in muscle movement.
    • Neuromuscular junctions begin to grow during fetal development.
      By: hartphotography
      Neuromuscular junctions begin to grow during fetal development.
    • Neurons are specially designed cells that communicate using chemicals called neurotransmitters.
      By: kateryna zakorko
      Neurons are specially designed cells that communicate using chemicals called neurotransmitters.
    • Myasthenia gravis tends to be more concentrated along skeletal muscles.
      By: Balint Radu
      Myasthenia gravis tends to be more concentrated along skeletal muscles.
    • Our bodies contain trillions of synapse "data" connections, many of which are constantly active.
      By: rolffimages
      Our bodies contain trillions of synapse "data" connections, many of which are constantly active.