Which Important Part of the Human Body Doesn’t Have a Direct Blood Supply?

The cornea is undoubtedly one of the human body’s most incredible structures. It’s the transparent portion of the eye that covers the iris, pupil, and anterior chamber, helping to refract light and contributing most of the eye’s focusing power.

To allow you to see, the cornea must be transparent, so it is avascular, which means it doesn’t have any blood vessels. Yet it is a living tissue that requires oxygen to survive. This raises an interesting question: how does oxygen reach the cornea if it doesn’t have a direct blood supply? After all, the vast majority of tissues depend on oxygen transported around the body by blood.

Diffusion is the key to providing the cornea with the oxygen and nutrients it needs to stay healthy. On the outside of the eye, tear fluid comes into contact with the air and brings essential nutrients to the cornea. Inside the eye, the aqueous humour delivers oxygen via simple diffusion to the back of the cornea.

When you are asleep, the cornea still has access to oxygen via exposure to the palpebral conjunctiva (the lining of your eyelids). This extensive blood vessel network comes into contact with the tear film on your cornea, thus allowing oxygen and nutrients to reach the cornea even when your eyes are closed. However, when closed, your eyes only receive around one-third of the oxygen they get from the air when you are awake.

When the cornea is deprived of oxygen from outside the eye, it can develop blood vessels—a process known as corneal neovascularization—which can severely impact your vision. In extreme cases, this can happen to contact lens users who keep their lenses in while sleeping, though it is less common with silicon hydrogel lenses. When awake, contact lenses move a tiny amount (around a millimeter per blink) to allow oxygen in. Yet this doesn’t happen when you’re asleep, and neither does the cornea come into contact with the palpebral conjunctiva. Wearing contact lenses overnight is also associated with infections, corneal ulcers, and keratitis.

The incredible cornea: